ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Atherosclerosis And Systemic Autoimmune Inflammatory Diseases: Review
Dr. Nurşen DÜZGÜNa,Dr. Erden ATTİLLAb
aKlinik İmmünoloji ve Romatoloji BD,bİç Hastalıkları AD,Ankara Üniversitesi Tıp Fakültesi,Ankara
Atherosclerosis is defined as a metabolic and inflammatory disease. Several inflammatory and immunologic factors were established that contributed significantly to atherogenesis. Atherosclerotic lesions contain active immune cells including macrophages and T cells, proinflammatory cytokines and adhesion molecules. Both humoral and cellular immune mechanisms have a major role in the onset and/or progression of atheromatous lesions. Oxidized low-density lipoprotein (OxLDL), heat shock proteins (HSPs) and beta 2-glycoprotein I (β2-GPI) are implicated to be the major antigens in atherogenesis. Circulating autoantibodies (e. g. antiOxLDL, antiβ2-GPI) against these antigens and/or immune complexes (e.g. OxLDL-antiOxLDL and /or β2-GPI-antiβ2-GPI) within atherosclerotic plaques were detected in both experimental animals and humans. The association of systemic autoimmune inflammatory diseases with atherosclerosis, suggests a similar pathogenic mechanism. The pathogenesis of early or accelerated atherosclerosis in autoimmune diseases is complex and multifactorial. Accelerated atherosclerosis, is a major cause of mortality in systemic lupus erythematosus and antiphospholipid syndrome. Early diagnosis of atherosclerosis, aggressive management of classical risk factors for cardiovascular disease, suppression of systemic inflammation and addition of preventive therapies may reduce the long-term burden of cardiovascular morbidity and mortality in patients with systemic autoimmune disease. In addition, new immunomodulatory treatment strategies are needed.Keywords: Atherosclerosis; autoimmune diseasesTurkiye Klinikleri J Med Sci 2008, 28:508-512
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