ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Prolonged Elevation Of Parathyroid Hormone In Normocalcemic Patient After Parathyroidectomy For Primary Hyperparathyroidism:association With Vitamin D: Case Report
Şebnem AKTARAN, MDa,Ersin AKARSU, MDa
aDepartment of endocrinology and Metabolism, Gaziantep University Faculty of Medicine, Gaziantep
We present a case report of normocalcemic patient with a prolonged elevation of parathyroid hormone (PTH)and low levels of 1,25(OH)2D3 after parathyroidectomy. A 48-year-old man presented with a 3-month history of fatigue. Clinical findings and radiological examinations revealed an ectopic parathyroid adenoma. After parathyroidectomy, he was normocalcemic but he had a low level of serum 1,25(OH)2D3 and urinary excretion of nephrogenous cyclic adenosine monophosphate (NcAMP) regardless of his persistently elevated PTH. Calcium and vitamin D replacement were initiated. Both PTH and 1,25(OH)2D3 gradually normalized within the 19 months after parathyroidectomy. In conclusion, several conditions may account for this secondary hyperparathyroidism (sHPT) in this patient including low levels of preoperative vitamin D, impaired renal function, bone remineralization and a large adenoma. In addition, postoperative renal resistance to PTH may be related to long lasting pimary hyperparathyroidism (pHPT) and sHPT.Keywords: Hyperparathyroidism, primary; surgeryTurkiye Klinikleri J Med Sci 2008, 28:580-583
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